PittsburghV1, France, Analysis, bibRecord, 000315

Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial

Identifieur interne : 000315 ( France/Analysis ); précédent : 000314; suivant : 000316

Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial

Auteurs : Andrew D. Althouse [États-Unis] ; J. Dawn Abbott [États-Unis] ; Alan D. Forker [États-Unis] ; Marnie Bertolet [États-Unis] ; Emma Barinas-Mitchell [États-Unis] ; Rebecca C. Thurston [États-Unis] ; Suresh Mulukutla [États-Unis] ; Victor Aboyans [France] ; Maria Mori Brooks [États-Unis]

Source :

Diabetes care [ 0149-5992 ] ; 2014.

RBID : Pascal:14-0129188

Descripteurs français

Pascal (Inist)
- Artériopathie oblitérante, Facteur risque, Incident, Diabète de type 2, Membre inférieur, Résultat, Dérivation, Angioplastie, Revascularisation, Dilatation instrumentale, Essai clinique, Endocrinologie, Maladie métabolique, Nutrition, Homme, Traitement instrumental.
Wicri :
- topic : Nutrition, Homme.

English descriptors

KwdEn :
- Angioplasty, Bypass, Clinical trial, Endocrinology, Human, Instrumental dilatation, Instrumentation therapy, Lower limb, Metabolic diseases, Mishap, Nutrition, Occlusive arterial disease, Result, Revascularization, Risk factor, Type 2 diabetes.

Abstract

OBJECTIVE The aim of this article was to define risk factors for incidence of peripheral arterial disease (PAD) in a large cohort of patients with type 2 diabetes mellitus (T2DM), overall and within the context of differing glycemic control strategies. RESEARCH DESIGN AND METHODS The Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) randomized controlled trial assigned participants to insulin-sensitizing (IS) therapy versus insulin-providing (IP) therapy. A total of 1,479 participants with normal ankle-brachial index (ABI) at study entry were eligible for analysis. PAD outcomes included new ABI ≤0.9 with decrease at least 0.1 from baseline, lower extremity revascularization, or lower extremity amputation. Baseline risk factors within the overall cohort and time-varying risk factors within each assigned glycemic control arm were assessed using Cox proportional hazards models. RESULTS During an average 4.6 years of follow-up, 303 participants (20.5%) experienced an incident case of PAD. Age, sex, race, and baseline smoking status were all significantly associated with incident PAD in the BARI 2D cohort. Additional baseline risk factors included pulse pressure, HbA_1c, and albumin-to-creatinine ratio (P < 0.05 for each). In stratified analyses of time-varying covariates, changes in BMI, LDL, HDL, systolic blood pressure, and pulse pressure were most predictive among IS patients, while change in HbA_1c was most predictive among IP patients. CONCLUSIONS Among patients with T2DM, traditional cardiovascular risk factors were the main predictors of incident PAD cases. Stratified analyses showed different risk factors were predictive for patients treated with IS medications versus those treated with IP medications.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994929

Affiliations:

Links to Exploration step

Pascal:14-0129188

Le document en format XML

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<settlement type="city">Limoges</settlement>
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<author><name sortKey="Brooks, Maria Mori" sort="Brooks, Maria Mori" uniqKey="Brooks M" first="Maria Mori" last="Brooks">Maria Mori Brooks</name>
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<series><title level="j" type="main">Diabetes care</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angioplasty</term>
<term>Bypass</term>
<term>Clinical trial</term>
<term>Endocrinology</term>
<term>Human</term>
<term>Instrumental dilatation</term>
<term>Instrumentation therapy</term>
<term>Lower limb</term>
<term>Metabolic diseases</term>
<term>Mishap</term>
<term>Nutrition</term>
<term>Occlusive arterial disease</term>
<term>Result</term>
<term>Revascularization</term>
<term>Risk factor</term>
<term>Type 2 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Artériopathie oblitérante</term>
<term>Facteur risque</term>
<term>Incident</term>
<term>Diabète de type 2</term>
<term>Membre inférieur</term>
<term>Résultat</term>
<term>Dérivation</term>
<term>Angioplastie</term>
<term>Revascularisation</term>
<term>Dilatation instrumentale</term>
<term>Essai clinique</term>
<term>Endocrinologie</term>
<term>Maladie métabolique</term>
<term>Nutrition</term>
<term>Homme</term>
<term>Traitement instrumental</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Nutrition</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE The aim of this article was to define risk factors for incidence of peripheral arterial disease (PAD) in a large cohort of patients with type 2 diabetes mellitus (T2DM), overall and within the context of differing glycemic control strategies. RESEARCH DESIGN AND METHODS The Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) randomized controlled trial assigned participants to insulin-sensitizing (IS) therapy versus insulin-providing (IP) therapy. A total of 1,479 participants with normal ankle-brachial index (ABI) at study entry were eligible for analysis. PAD outcomes included new ABI ≤0.9 with decrease at least 0.1 from baseline, lower extremity revascularization, or lower extremity amputation. Baseline risk factors within the overall cohort and time-varying risk factors within each assigned glycemic control arm were assessed using Cox proportional hazards models. RESULTS During an average 4.6 years of follow-up, 303 participants (20.5%) experienced an incident case of PAD. Age, sex, race, and baseline smoking status were all significantly associated with incident PAD in the BARI 2D cohort. Additional baseline risk factors included pulse pressure, HbA<sub>1c</sub>
, and albumin-to-creatinine ratio (P < 0.05 for each). In stratified analyses of time-varying covariates, changes in BMI, LDL, HDL, systolic blood pressure, and pulse pressure were most predictive among IS patients, while change in HbA<sub>1c</sub>
 was most predictive among IP patients. CONCLUSIONS Among patients with T2DM, traditional cardiovascular risk factors were the main predictors of incident PAD cases. Stratified analyses showed different risk factors were predictive for patients treated with IS medications versus those treated with IP medications.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Limousin</li>
<li>Nouvelle-Aquitaine</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Limoges</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
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<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Althouse, Andrew D" sort="Althouse, Andrew D" uniqKey="Althouse A" first="Andrew D." last="Althouse">Andrew D. Althouse</name>
</region>
<name sortKey="Barinas Mitchell, Emma" sort="Barinas Mitchell, Emma" uniqKey="Barinas Mitchell E" first="Emma" last="Barinas-Mitchell">Emma Barinas-Mitchell</name>
<name sortKey="Bertolet, Marnie" sort="Bertolet, Marnie" uniqKey="Bertolet M" first="Marnie" last="Bertolet">Marnie Bertolet</name>
<name sortKey="Brooks, Maria Mori" sort="Brooks, Maria Mori" uniqKey="Brooks M" first="Maria Mori" last="Brooks">Maria Mori Brooks</name>
<name sortKey="Dawn Abbott, J" sort="Dawn Abbott, J" uniqKey="Dawn Abbott J" first="J." last="Dawn Abbott">J. Dawn Abbott</name>
<name sortKey="Forker, Alan D" sort="Forker, Alan D" uniqKey="Forker A" first="Alan D." last="Forker">Alan D. Forker</name>
<name sortKey="Mulukutla, Suresh" sort="Mulukutla, Suresh" uniqKey="Mulukutla S" first="Suresh" last="Mulukutla">Suresh Mulukutla</name>
<name sortKey="Thurston, Rebecca C" sort="Thurston, Rebecca C" uniqKey="Thurston R" first="Rebecca C." last="Thurston">Rebecca C. Thurston</name>
<name sortKey="Thurston, Rebecca C" sort="Thurston, Rebecca C" uniqKey="Thurston R" first="Rebecca C." last="Thurston">Rebecca C. Thurston</name>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Aboyans, Victor" sort="Aboyans, Victor" uniqKey="Aboyans V" first="Victor" last="Aboyans">Victor Aboyans</name>
</region>
</country>
</tree>
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{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:14-0129188
   |texte=   Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial
}}

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Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial

Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial

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